SAPI may stand for:

• Speech Application Programming Interface, an API produced by Microsoft for speech recognition and speech synthesis
• Server Application Programming Interface, an API used to interface with web servers such as Apache
• Small Arms Protective Insert, a military ballistic protection system
• Systém automatického pořizování informací (system for automatic gathering of information): SAPI-1, a computer produced in former Czechoslovakia by Tesla
• Network Service Access Point Identifier, an identifier used in GPRS (cellular data) networks.
• SaPI, a family of pathogenicity islands found in Staphylococcus aureus

Sapi may refer to:

• Sapi Safari Area, included in UNESCO World Heritage Site Mana Pools National Park, Sapi and Chewore Safari Areas
• Sapi, a nickname for the name Sapna found in the Hindi language. Usage has been documented in North Eastern Ohio.
• Bull in Indonesian, such as in the Karapan sapi event or various dishes in Indonesian cuisine